Well... everything happens slower in a full scale heli and your orientation never changes, that has to make it easier, especially if you really learn your helicopter flight physics from your rc helis. I've heard it said that it's way easier to go from rc to full scale than the other way around.
I saw a video recently where a MD500 pilot flew a trex600 (first time with rc). He was able to hover - a little - but it kept getting too far away from him... I'll try to find that.